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Comput Struct Biotechnol J. 2014 Jun 11;10(16):1-7. doi: 10.1016/j.csbj.2014.05.006. eCollection 2014 Jun.

The role of genetic polymorphisms of the Renin-Angiotensin System in renal diseases: A meta-analysis.

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Department of Computer Science and Biomedical Informatics, University of Thessaly, Lamia 35100, Greece.


Renal failure has a complex phenotype resulting from an underlying kidney disease as well as environmental and genetic factors. In the present study we performed a systematic review and meta-analyses to evaluate the association of the A1166C polymorphism of Angiotensin II type 1 Receptor gene (AGTR1) with Chronic Kidney Disease (CKD), End Stage Renal Disease (ESRD), IgA Nephropathy (IgAN) and Vesicoureteral Reflux (VUR) as well as the association of A1332G polymorphism of Angiotensin II type 2 Receptor (AGTR2) gene with Vesicoureteral Reflux (VUR). We found that neither AGTR1 Α1166C, nor AGTR2 A1332G polymorphisms were significantly associated with any of the aforementioned renal diseases, suggesting that they cannot be used as predictive markers in either general or subgroup ethnic populations.


Angiotensin receptor; CKD; ESRD; Genetic association; Kidney disease; Polymorphism

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