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J Pharmacol Pharmacother. 2014 Jul;5(3):193-6. doi: 10.4103/0976-500X.136101.

Effects of glucocorticoids and tumor necrosis factor-alpha inhibitors on both clinical and molecular parameters in patients with Takayasu arteritis.

Author information

1
Department of Medical and Surgical Science, Interuniversity Center of Phlebolymphology, International Research and Educational Program in Clinical and Experimental Biotechnology, Catanzaro, Italy.
2
Department of Surgery, Unit of Vascular Surgery, Annunziata Hospital of Cosenza, Cosenza, Italy.
3
Department of Pharmacological, Biological and Chemical Science, University of Parma, Parma, Italy.
4
Department of Health Science, University Magna Graecia of Catanzaro, Catanzaro, Italy.

Abstract

OBJECTIVE:

To explore the effect of sequential treatment with glucocorticoid and tumor necrosis factor-alpha inhibitors in patients with Takayasu arteritis (TA).

MATERIALS AND METHODS:

In five patients with TA, the effects of the sequential treatment with prednisone for 5-7 months and then with adalimumab (ADA) + methotrexate (MTX) or infliximab + MTX, or with ADA only, for 12 months on both clinical and laboratory findings were evaluated.

RESULTS:

All treatments improved both symptoms and laboratory parameters without the development of side-effects.

CONCLUSIONS:

It was hypothesized that MMP-9 and neutrophil gelatinase-associated lipocalin could be markers of the response to the treatments.

KEYWORDS:

Adalimumab; infliximab; matrix metalloproteinases-9; methotrexate; neutrophil gelatinase-associated lipocalin; takayasu arteritis

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