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Sci Rep. 2014 Sep 11;4:6328. doi: 10.1038/srep06328.

Changes of the human gut microbiome induced by a fermented milk product.

Author information

1
Danone Nutricia Research, Palaiseau, France.
2
INRA, Metagenopolis, Jouy-en-Josas, France.
3
Neurogastroenterology Unit, University of Manchester, Manchester, United Kingdom.
4
C2R, Paris, France.
5
1] Centre for Gastrointestinal Sciences, University of Manchester, University Hospital of South Manchester, Manchester, United Kingdom [2] Division of Gastroenterology and Hepatology, Mayo Clinic, Florida, USA.
6
Centre for Gastrointestinal Sciences, University of Manchester, University Hospital of South Manchester, Manchester, United Kingdom.
7
1] INRA, Metagenopolis, Jouy-en-Josas, France [2] Centre for Human Microbiome Interactions, King's College London, London, United Kingdom.

Abstract

The gut microbiota (GM) consists of resident commensals and transient microbes conveyed by the diet but little is known about the role of the latter on GM homeostasis. Here we show, by a conjunction of quantitative metagenomics, in silico genome reconstruction and metabolic modeling, that consumption of a fermented milk product containing dairy starters and Bifidobacterium animalis potentiates colonic short chain fatty acids production and decreases abundance of a pathobiont Bilophila wadsworthia compared to a milk product in subjects with irritable bowel syndrome (IBS, n = 28). The GM changes parallel improvement of IBS state, suggesting a role of the fermented milk bacteria in gut homeostasis. Our data challenge the view that microbes ingested with food have little impact on the human GM functioning and rather provide support for beneficial health effects.

PMID:
25209713
PMCID:
PMC4160712
DOI:
10.1038/srep06328
[Indexed for MEDLINE]
Free PMC Article

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