Send to

Choose Destination
Crit Rev Food Sci Nutr. 2016;56(4):635-40. doi: 10.1080/10408398.2012.747484.

Mediterranean Way of Drinking and Longevity.

Author information

a Department of Surgery , University of Genoa , Genoa , Italy.
b Department of Gastroenterology , Policlinico di Monza , Monza , Italy.
c Department of Biology , University of Pisa , Pisa , Italy.
d CRA-Research Centre for Viticulture , Conegliano , Italy.
e ASP (Azienda di Servizi alla Persona) of Pavia , Pavia , Italy.
f Va. PRA, Microbiology and Food Technology Sector, University of Turin , Grugliasco , Italy.
g Mario Negri Institute for Pharmacological Research , Milan , Italy.
h Department of Occupational Health , University of Milan , Milan , Italy.
i Department of Biotechnology , University of Verona , Verona , Italy.
j Department of Applied Health Science , University of Pavia , Pavia , Italy.


The relation between alcohol consumption and mortality is a J-shaped curve in most of the many studies published on this topic. The Copenhagen Prospective Population Studies demonstrated in the year 2000 that wine intake may have a beneficial effect on all cause mortality that is additive to that of alcohol. Wine contains various poliphenolic substances which may be beneficial for health and in particular flavonols (such as myricetin and quercetin), catechin and epicatechin, proanthocyanidins, anthocyanins, various phenolic acids and the stilbene resveratrol. In particular, resveratrol seems to play a positive effect on longevity because it increases the expression level of Sirt1, besides its antioxidant, anti-inflammatory and anticarcinogenic properties. Moderate wine drinking is part of the Mediterranean diet, together with abundant and variable plant foods, high consumption of cereals, olive oil as the main (added) fat and a low intake of (red) meat. This healthy diet pattern involves a "Mediterranean way of drinking," that is a regular, moderate wine consumption mainly with food (up to two glasses a day for men and one glass for women). Moderate wine drinking increases longevity, reduces the risk of cardiovascular diseases and does not appreciably influence the overall risk of cancer.


Alcohol; Mediterranean diet; longevity; resveratrol; wine

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center