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Nat Rev Mol Cell Biol. 2014 Oct;15(10):677-89. doi: 10.1038/nrm3869. Epub 2014 Sep 10.

Capping protein regulators fine-tune actin assembly dynamics.

Author information

Department of Cell Biology and Physiology, Washington University, St. Louis, Missouri 63110, USA.
Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Departments of Biology and Cell Biology, University of Virginia, Charlottesville, Virginia 22904, USA.
Department of Biomedical Engineering and Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.

Erratum in

  • Nat Rev Mol Cell Biol. 2014 Nov;15(11):701.


Capping protein (CP) binds the fast growing barbed end of the actin filament and regulates actin assembly by blocking the addition and loss of actin subunits. Recent studies provide new insights into how CP and barbed-end capping are regulated. Filament elongation factors, such as formins and ENA/VASP (enabled/vasodilator-stimulated phosphoprotein), indirectly regulate CP by competing with CP for binding to the barbed end, whereas other molecules, including V-1 and phospholipids, directly bind to CP and sterically block its interaction with the filament. In addition, a diverse and unrelated group of proteins interact with CP through a conserved 'capping protein interaction' (CPI) motif. These proteins, including CARMIL (capping protein, ARP2/3 and myosin I linker), CD2AP (CD2-associated protein) and the WASH (WASP and SCAR homologue) complex subunit FAM21, recruit CP to specific subcellular locations and modulate its actin-capping activity via allosteric effects.

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