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Neural Regen Res. 2014 May 1;9(9):968-72. doi: 10.4103/1673-5374.133148.

Acupuncture and moxibustion reduces neuronal edema in Alzheimer's disease rats.

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Hubei University of Chinese Medicine, Wuhan, Hubei Province, China.


To examine the possible correlation of aberrant Wnt signaling and pathological changes in Alzheimer's disease, we established a rat model of Alzheimer's disease and measured axin and β-catenin expression in the hippocampus. Rats were pretreated with moxibustion or electroacupuncture, or both, at Baihui (GV20) and Shenshu (BL23). Axin expression was lower, β-catenin expression was greater, and neuronal cytoplasmic edema was visibly prevented in the rats that had received the pretreatments. Our results suggest that the mechanism underlying the neuroprotective effect of acupuncture and moxibustion in Alzheimer's disease is associated with axin and β-catenin expression in the Wnt signal transduction pathway.


Alzheimer's disease; NSFC grant; acupuncture and moxibustion; axin; brain injury; nerve regeneration; neural regeneration; pretreatment; β-catenin

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