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Neural Regen Res. 2014 Feb 1;9(3):260-7. doi: 10.4103/1673-5374.128218.

Polysaccharides from Angelica sinensis alleviate neuronal cell injury caused by oxidative stress.

Author information

1
Department of Rehabilitation Medicine, Zhongnan Hospital and Cerebral Vascular Diseases Research Center, Zhongnan Hospital, Wuhan University, Wuhan, Hubei Province, China.
2
School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei Province, China.

Abstract

Angelica sinensis has antioxidative and neuroprotective effects. In the present study, we aimed to determine the neuroprotective effect of polysaccharides isolated from Angelica sinensis. In a preliminary experiment, Angelica sinensis polysaccharides not only protected PC12 neuronal cells from H2O2-induced cytotoxicity, but also reduced apoptosis and intracellular reactive oxygen species levels, and increased the mitochondrial membrane potential induced by H2O2 treatment. In a rat model of local cerebral ischemia, we further demonstrated that Angelica sinensis polysaccharides enhanced the antioxidant activity in cerebral cortical neurons, increased the number of microvessels, and improved blood flow after ischemia. Our findings highlight the protective role of polysaccharides isolated from Angelica sinensis against nerve cell injury and impairment caused by oxidative stress.

KEYWORDS:

Angelica sinensis; NSFC grant; antioxidation; apoptosis; cerebral ischemia; microvessels; mitochondrial membrane potential; nerve regeneration; neural regeneration; polysaccharides; reactive oxygen species

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