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Neural Regen Res. 2014 Jun 15;9(12):1210-6. doi: 10.4103/1673-5374.135329.

Autophagy: a double-edged sword for neuronal survival after cerebral ischemia.

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Department of Neurology, the Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China.
Zhoupu Hospital, Pudong New District, Shanghai, China.


Evidence suggests that autophagy may be a new therapeutic target for stroke, but whether activation of autophagy increases or decreases the rate of neuronal death is still under debate. This review summarizes the potential role and possible signaling pathway of autophagy in neuronal survival after cerebral ischemia and proposes that autophagy has dual effects.


NSFC grant; apoptosis; autophagosome; autophagy; cerebral ischemia; lysosome; necrosis; nerve regeneration; neural regeneration; neuron; signaling pathway; survival

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