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Front Pharmacol. 2014 Aug 26;5:196. doi: 10.3389/fphar.2014.00196. eCollection 2014.

Glutathione: new roles in redox signaling for an old antioxidant.

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Department of Biology, University of Rome Tor Vergata Rome, Italy.
Scientific Institute for Research, Hospitalization and Health Care, Università Telematica San Raffaele Roma Rome, Italy.


The physiological roles played by the tripeptide glutathione have greatly advanced over the past decades superimposing the research on free radicals, oxidative stress and, more recently, redox signaling. In particular, GSH is involved in nutrient metabolism, antioxidant defense, and regulation of cellular metabolic functions ranging from gene expression, DNA and protein synthesis to signal transduction, cell proliferation and apoptosis. This review will be focused on the role of GSH in cell signaling by analysing the more recent advancements about its capability to modulate nitroxidative stress, autophagy, and viral infection.


autophagy; nitric oxide; reactive oxygen species; redox signal; viral infection

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