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Ann Neurosci. 2014 Jan;21(1):28-31. doi: 10.5214/ans.0972.7531.210109.

Sonic hedgehog signalling pathway: a complex network.

Author information

1
Douglas Hospital Research Centre, Montreal, Quebec, Canada, H4H 1R3; ; Department of Human Genetics, McGill University, Montreal, Quebec, Canada, H3H 1B1; ; Division of Research & Medical Education, International Maternal and Child Health Foundation, Montreal, QC, Canada, H7S 2N5;
2
Douglas Hospital Research Centre, Montreal, Quebec, Canada, H4H 1R3; ; Department of Psychiatry, McGill University, Montreal, Quebec, Canada, H3A 1A1;
3
Division of Research & Medical Education, International Maternal and Child Health Foundation, Montreal, QC, Canada, H7S 2N5;
4
Department of Dental Sciences, Clifton Hospital, Karachi, Sindh, Pakistan, 71000;
5
Millbourne Mall Medical Centre, Primary Care Network Edmonton, AB, Canada, T6T 1L5,; ; Meadowbrook Medical Clinic, Primary Care Network, Edmonton, AB, Canada, T6T 1L5;
6
Faculty of Pharmacy & Pharmaceutical Science, University of Alberta, Edmonton, Canada, T6G 2P4;
7
Medicentres, Edmonton, AB, Canada, T6L 6N3;
8
Jinnah Post Graduate Medical Centre, Karachi, Sindh, Pakistan, 71000;
9
Institute of Integrated Cell-Material Science, Kyoto University, Yoshida Ushinomiyacho, Sakyo-ku, Japan, 606-8501.

Abstract

Sonic Hedgehog (Shh) signalling cascade is one of the intricate signal transduction mechanisms that govern the precisely regulated developmental processes of multicellular organisms. Along with establishing the patterns of cellular differentiation to direct complex organ formation, it also has an important role in post-embryonic tissue regeneration and repair processes. Especially, Shh signalling is implicated in the induction of multifarious neuronal populations in central nervous system. There is compelling evidence of the involvement of Shh protein in the signalling network that regulates various morphogenetic processes such as the exquisite neural tube pattern formation. In the morphogenetic field, the activation of Shh signalling processes is intricately linked to the alterations at the molecular level in the structure of Shh protein that leads to its altered biophysical and biochemical reactivity. This brief article gives an overview of such complex cascade of events in Shh signalling and its transduction pathways.

KEYWORDS:

Autoproteolysis; Holoprosencephaly; Lipidation; Neural tube pattern; Notochord; Sonic hedgehog

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