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Biol Chem. 2014 Nov 1;395(11):1341-52. doi: 10.1515/hsz-2014-0178.

Titin: central player of hypertrophic signaling and sarcomeric protein quality control.

Abstract

The giant sarcomeric protein titin has multiple important functions in striated muscle cells. Due to its gigantic size, its central position in the sarcomere and its elastic I-band domains, titin is a scaffold protein that is important for sarcomere assembly, and serves as a molecular spring that defines myofilament distensibility. This review focuses on the emerging role of titin in mechanosensing and hypertrophic signaling, and further highlights recent evidence that links titin to sarcomeric protein turnover.

PMID:
25205716
DOI:
10.1515/hsz-2014-0178
[Indexed for MEDLINE]

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