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Eur J Clin Nutr. 2015 Feb;69(2):247-55. doi: 10.1038/ejcn.2014.154. Epub 2014 Sep 10.

Inflammation profile in overweight/obese adolescents in Europe: an analysis in relation to iron status.

Collaborators (226)

Moreno LA, Gottrand F, De Henauw S, González-Gross M, Gilbert C, Kafatos A, Moreno LA, Libersa C, De Henauw S, Sáchez J, Gottrand F, Kesting M, Sjostrom M, Molnár D, González-Gross M, Dallongeville J, Gilbert C, Hall G, Maes L, Scalfi L, Meléndez P, Moreno LA, Fleta J, Casajús JA, Rodríguez G, Tomás C, Mesana MI, Vicente-Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Fernández Alvira J, Bueno G, Aurora Lázaro, Bueno O, León JF, Garagorri JM, Bueno M, López JP, Iglesia I, Velasco P, Bel S, Marcos A, Wärnberg J, Nova E, Gómez S, Díaz EL, Romeo J, Veses A, Puertollano MA, Zapatera B, Pozo T, Beghin L, Libersa C, Gottrand F, Iliescu C, Von Berlepsch J, Kersting M, Sichert-Hellert W, Koeppen E, Molnar D, Erhardt E, Csernus K, Török K, Bokor S, Nagy E, Kovács O, Repásy J, Kafatos A, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Sbokos CV, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, González-Gross M, Breidenassel C, Spinneker A, Al-Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Picker P, Castillo MJ, Gutiérrez Á, Ortega FB, Ruiz JR, Artero EG, España-Romero V, Jiménez-Pavón D, Chillón P, Cuenca-Garcia M, Arcella D, Azzini E, Barrison E, Bevilacqua N, Buonocore P, Catasta G, Censi L, Ciarapica D, D'Acapito P, Ferrari M, Galfo M, Donne CL, Leclercq C, Maiani G, Mauro B, Mistura L, Pasquali A, Piccinelli R, Polito A, Spada R, Sette S, Zaccaria M, Scalfi L, Vitaglione P, Montagnese C, De Henauw S, De Vriendt T, Maes L, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Huybrechts I, Widhalm K, Phillipp K, Dietrich S, Manios Y, Grammatikaki E, Bouloubasi Z, Cook TL, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Dallongeville J, Meirhaeghe A, Sjöstrom M, Bergman P, Hagströmer M, Hallström L, Hallberg M, Poortvliet E, Wärnberg J, Rizzo N, Beckman L, Wennlöf AH, Patterson E, Kwak L, Cernerud L, Tillgren P, Sörensen S, Sánchez-Molero J, Picó E, Navarro M, Viadel B, Carreres JE, Merino G, Sanjuán R, Lorente M, Sánchez MJ, Gilbert C, Thomas S, Allchurch E, Burgess P, Hall G, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, von Fircks H, Hallberg ML, Messerer M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, González-Gross M, Valtueña J, Jiménez-Pavón D, Albers U, Pedrero R, Meléndez A, Benito PJ, Gómez Lorente JJ, Cañada D, Urzanqui A, Ortiz JC, Fuentes F, Torres RM, Navarro P.

Author information

1
CRA-NUT, Agricultural Research Council-Food and Nutrition Research Centre, Rome, Italy.
2
Department of Medical Physiology, School of Medicine, Granada University, Granada, Spain.
3
1] CRA-NUT, Agricultural Research Council-Food and Nutrition Research Centre, Rome, Italy [2] ImFine Research Group, Department of Health and Human Performance, Facultad de Ciencias de la Actividad Fisica y del Deporte-INEF, Universidad Politécnica de Madrid, Madrid, Spain.
4
1] GENUD (Growth, Exercise, Nutrition and Development) research group, E.U. Ciencias de la Salud, Universidad de Zaragoza, Zaragoaza, Spain [2] Visiting Professor, School of Medicine of the University of São Paulo - Department of Preventive Medicine, São Paulo, Brazil.
5
1] ImFine Research Group, Department of Health and Human Performance, Facultad de Ciencias de la Actividad Fisica y del Deporte-INEF, Universidad Politécnica de Madrid, Madrid, Spain [2] Department of Nutrition and Food Sciences-Nutritional Physiology, University of Bonn, Bonn, Germany.
6
Department of Nutrition and Dietetics, Harakopio University, Athens, Greece.
7
Department of Consumer & Sensory Sciences, Campden BRI, Gloucestershire, UK.
8
International Agency for research on Cancer (IARC), Dietary Exposure Assessment group, Lyon, France.
9
INSERM U744, Institut Pasteur de Lille, Univesité Lille Nord de France, Lille, France.
10
Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
11
Department of Paediatrics, University of Pécs, Pécs-József A.7, Hungary.
12
1] Ghent University, Department of Public Health, University Hospital, Ghent, Belgium [2] University College Ghent, Department of Nutrition and Dietetics, Faculty of Health Care 'Vesalius', Ghent, Belgium.
13
Immunonutrition Research Group, Department of Metabolism and Nutrition, Spanish Council for Scientific Research (CSIC), Madrid, Spain.
14
1] GENUD (Growth, Exercise, Nutrition and Development) research group, E.U. Ciencias de la Salud, Universidad de Zaragoza, Zaragoaza, Spain [2] School of Medicine of the University of São Paulo - Post-Graduate Program in Science, Department of Preventive Medicine, São Paulo/SP, Brazil.
15
Department of Social Medicine, Preventive Medicine and Nutrition Clinic, School of Medicine, University of Crete, Crete, Greece.
16
Department of Paediatrics and Adolescents Medicine, Division of Clinical Nutrition, Private Medical University of Salzburg, Salzburg, Austria.

Abstract

BACKGROUND/OBJECTIVES:

The objectives of this study were to investigate the relationship between inflammatory parameters (CRP, c-reactive protein; AGP, α1-acid glycoprotein), iron status indicators (SF, serum ferritin; sTfR, soluble transferrin receptor) and body mass index (BMI) z-score, fat-free mass (FFM) and fat mass (FM) in European adolescents. Differences in intake for some nutrients (total iron, haem and non-haem iron, vitamin C, calcium, proteins) were assessed according to BMI categories, and the association of nutrient intakes with BMI z-score, FM and FFM was evaluated.

METHODS:

A total of 876 adolescents participating in the Healthy Lifestyle in Europe by Nutrition in Adolescence-Cross Sectional Study were included in the study sample.

RESULTS:

Mean CRP values (standard error; s.e.) were significantly higher in overweight/obese adolescents (1.7±0.3 and 1.4±0.3 mg/l in boys and girls, respectively) than in thin/normal-weight adolescents (1.1±0.2 and 1.0±0.1 mg/l in boys and girls, respectively) (P<0.05). For boys, mean SF values (s.e.) were significantly higher in overweight/obese adolescents (46.9±2.7 μg/l) than in thin/normal-weight adolescents (35.7±1.7 μg/l) (P<0.001), whereas median sTfR values did not differ among BMI categories for both boys and girls. Multilevel regression analyses showed that BMI z-score and FM were significantly related to CRP and AGP (P<0.05). Dietary variables did not differ significantly among BMI categories, except for the intake of vegetable proteins, which, for boys, was higher in thin/normal-weight adolescents than in overweight/obese adolescents (P<0.05).

CONCLUSIONS:

The adiposity of the European adolescents was sufficient to cause chronic inflammation but not sufficient to impair iron status and cause iron deficiency.

PMID:
25205319
DOI:
10.1038/ejcn.2014.154
[Indexed for MEDLINE]

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