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Cell Immunol. 2014 Sep-Oct;291(1-2):32-40. doi: 10.1016/j.cellimm.2014.07.007. Epub 2014 Aug 14.

Inflammatory monocyte effector mechanisms.

Author information

1
Albert Einstein College of Medicine, Department of Microbiology and Immunology, Bronx, NY 10461, USA. Electronic address: gregoire.lauvau@einstein.yu.edu.
2
Albert Einstein College of Medicine, Department of Microbiology and Immunology, Bronx, NY 10461, USA.

Abstract

Monocytes are blood-derived mononuclear phagocytic cells that traffic throughout the body and can provide rapid innate immune effector responses in response to microbial pathogen infections. Among blood monocytes, the most abundant subset in mice is represented by inflammatory Ly6C(+) CCR2(+) monocytes and is the functional equivalent of the CD14(+) monocytes in humans. Herein we focus on published evidence describing the exquisite functional plasticity of these cells, and we extend this overview to their multiples roles in vivo during host immune defenses against microbial pathogen infections, as antigen-presenting cells, inflammatory cells or Trojan horse cells.

KEYWORDS:

Antigen presentation; CCR2; Effector functions; Inflammatory Ly6C(+) monocytes; Microbial pathogens

PMID:
25205002
PMCID:
PMC4457438
DOI:
10.1016/j.cellimm.2014.07.007
[Indexed for MEDLINE]
Free PMC Article

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