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Clin Biochem. 2015 Mar;48(4-5):201-3. doi: 10.1016/j.clinbiochem.2014.08.021. Epub 2014 Sep 7.

IFCC educational materials on selected analytical and clinical applications of high sensitivity cardiac troponin assays.

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Department of Laboratory Medicine and Pathology, Hennepin County Medical Center and University of Minnesota, Minneapolis, MN, USA. Electronic address:
Cardiovascular Division, Mayo Clinic, Rochester,MN, USA.
Department of Cardiology, St George's Hospital, London, UK; Department of Clinical Blood Sciences, St George's Hospital, London, UK.
Department of Cardiology, Charité-University Medicine Berlin, Campus Virchow-Klinikum, Berlin, Germany.
Biochemistry Department, IIB-Sant Pau & Universitat Autònoma, Barcelona, Spain.
Department of Medical Sciences, Cardiology, and Uppsala Clinical Research Center, University of Uppsala, Sweden.
Department of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA, USA.
Department of Laboratory Medicine, University-Hospital, Padova, Italy.
Christchurch Hospital, Emergency Department, Christchurch, New Zealand.
Department of Chemical Pathology, Prince of Wales Hospital, Hong Kong, China.


In 2011, the IFCC Task Force on Clinical Applications of Cardiac Bio-Markers (TF-CB) was formed, with the purpose of providing evidence based educational materials to assist all biomarker users, i.e. laboratorians, clinicians, researchers, in-vitro diagnostics and regulatory agencies, in better understanding important analytical and clinical aspects of established and novel cardiac biomarkers for use in clinical practice and research. The goal of the task force was to promulgate the same information conjointly through the in vitro diagnostic industry to the laboratory, emergency department and cardiologists. The initial undertaking of the TF-CB, which is comprised of laboratory medicine scientists, emergency medicine physicians and cardiologists, was to address two key issues pertaining to implementing high-sensitivity cardiac troponin (hs-cTn) assays in clinical practice: the 99th percentile upper reference limit (URL) and calculating serial change values in accord with the Universal Definition of AMI. The highlights of both concepts from IFCC statements are described.


99th percentile; High-sensitivity cardiac troponin assays; IFCC; Myocardial infarction; Risk stratification

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