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J Biol Chem. 2014 Nov 14;289(46):31856-65. doi: 10.1074/jbc.M114.589093. Epub 2014 Sep 9.

The p38 pathway regulates oxidative stress tolerance by phosphorylation of mitochondrial protein IscU.

Author information

1
From the State Key Laboratory of Cellular Stress Biology and School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China.
2
the Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration (SOA), Xiamen, Fujian 361005, China, and chenjm@xmu.edu.cn.
3
the Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration (SOA), Xiamen, Fujian 361005, China, and.
4
the Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

Abstract

The p38 pathway is an evolutionarily conserved signaling pathway that responds to a variety of stresses. However, the underlying mechanisms are largely unknown. In the present study, we demonstrate that p38b is a major p38 MAPK involved in the regulation of oxidative stress tolerance in addition to p38a and p38c in Drosophila. We further show the importance of MK2 as a p38-activated downstream kinase in resistance to oxidative stresses. Furthermore, we identified the iron-sulfur cluster scaffold protein IscU as a new substrate of MK2 both in Drosophila cells and in mammalian cells. These results imply a new mechanistic connection between the p38 pathway and mitochondria iron-sulfur clusters.

KEYWORDS:

Iron-Sulfur Protein; Mitochondrial Aconitase; Oxidative Stress; p38; p38 MAPK

PMID:
25204651
PMCID:
PMC4231663
DOI:
10.1074/jbc.M114.589093
[Indexed for MEDLINE]
Free PMC Article

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