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Epileptic Disord. 2014 Sep;16(3):328-32. doi: 10.1684/epd.2014.0680.

Multifocal dysembryoplastic neuroepithelial tumours associated with refractory epilepsy.

Author information

1
Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda.
2
Department of Neurology, University of Alabama at Birmingham, Birmingham.
3
Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda.
4
Section of Neuroradiology, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda.
5
EEG Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda.
6
Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.

Abstract

Dysembryoplastic neuroepithelial tumours (DNET) are a common cause of tumour-associated epilepsy, and are usually located in the temporal lobes. We present a case of multifocal DNETs in both infra- and supra-tentorial locations, in a 23-year-old man with a coincident Type I Chiari malformation, presenting with medically refractory focal seizures. The extensive anatomical distribution of the lesions suggests a genetic component in their tumourigenesis.

KEYWORDS:

Chiari malformation; multi-focal tumor; tumor-associated epilepsy

PMID:
25204011
DOI:
10.1684/epd.2014.0680
[Indexed for MEDLINE]
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