Abstract
Ni-, Cu-, and Zn-TMPyP are capable of binding to single-strand poly(A) RNA with high preference and affinity and inhibiting the reverse transcription of RNA by both M-MuLV and HIV-1 reverse transcriptase. With 10 nM azidothymidine, the IC50 value of M-TMPyP could be lowered to 10(-1) μM order.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Binding Sites / drug effects
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Dose-Response Relationship, Drug
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Metals, Heavy / chemistry
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Molecular Conformation
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Moloney murine leukemia virus / enzymology
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Organometallic Compounds / chemistry
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Organometallic Compounds / pharmacology*
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Poly A / antagonists & inhibitors*
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Poly A / genetics
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Porphyrins / chemistry
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RNA, Viral / drug effects*
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RNA, Viral / genetics
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RNA-Directed DNA Polymerase / metabolism*
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Reverse Transcriptase Inhibitors / chemistry
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Reverse Transcriptase Inhibitors / pharmacology*
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Structure-Activity Relationship
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Transcription, Genetic / drug effects*
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Transcription, Genetic / genetics
Substances
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Metals, Heavy
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Organometallic Compounds
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Porphyrins
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RNA, Viral
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Reverse Transcriptase Inhibitors
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meso-tetrakis(N-methylpyridinium-4-yl)porphyrin
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Poly A
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RNA-Directed DNA Polymerase