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Anticancer Res. 2014 Sep;34(9):4969-75.

Preventive effects of probiotic bacteria Lactobacillus plantarum and dietary fiber in chemically-induced mammary carcinogenesis.

Author information

1
Institute of Biology and Ecology, Faculty of Science, P.J. Šafárik University, Košice, Slovak Republic monika.kassayova@upjs.sk.
2
Department of Forensic Medicine, Faculty of Medicine, P.J. Šafárik University, Košice, Slovak Republic.
3
Department of Experimental Medicine, Faculty of Medicine, P.J. Šafárik University, Košice, Slovak Republic.
4
Institute of Biology and Ecology, Faculty of Science, P.J. Šafárik University, Košice, Slovak Republic.
5
Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovak Republic.

Abstract

AIM:

The purpose of the present study was to evaluate the chemopreventive efficacy of a new probiotic bacterial strain, Lactobacillus plantarum LS/07 (PRO), prebiotic oligofructose-enriched inulin (PRE) and PRO-PRE combination in a rat model of breast cancer.

MATERIALS AND METHODS:

Mammary carcinogenesis was induced by 7,12-dimethylbenz[a]anthracene (DMBA). Daily oral administration of PRO (at a dose of 8.4×10(8) c.f.u./rat) and PRE (in the diet, 20 g/kg) started two weeks before the first DMBA dose and lasted until the end of the experiment (16 weeks).

RESULTS:

Administration of PRO, PRE and PRO-PRE combination significantly suppressed the tumor frequency, increased Cd4(+) T-cells in tumor tissue and reduced serum tumor necrosis factor-α concentration. In PRO and PRO-PRE groups, the decline of Cd8(+) T-cells in blood and their increase in tumor tissue was observed.

CONCLUSION:

Long-term administration of Lactobacillus plantarum LS/07 with and without inulin is effective against breast cancer, at least partially, through immunomodulatory mechanisms.

KEYWORDS:

7,12-dimethylbenz[a]anthracene; Breast cancer; Lactobacillus plantarum; oligofructose-enriched inulin; prebiotic; probiotic

PMID:
25202079
[Indexed for MEDLINE]

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