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Elife. 2014 Sep 8;3:e04395. doi: 10.7554/eLife.04395.

Mapping the zoonotic niche of Ebola virus disease in Africa.

Author information

1
Spatial Ecology and Epidemiology Group, Department of Zoology, University of Oxford, Oxford, United Kingdom.
2
Epidemic Diseases Research Group, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom.
3
Department of Medicine, Division of Infectious Diseases, University of Toronto, Toronto, Canada.
4
Department of Pediatrics, Harvard Medical School, Boston, United States.
5
Children's Hospital Informatics Program, Boston Children's Hospital, Boston, United States.
6
Department of Geography and Environment, University of Southampton, Southampton, United Kingdom.

Abstract

Ebola virus disease (EVD) is a complex zoonosis that is highly virulent in humans. The largest recorded outbreak of EVD is ongoing in West Africa, outside of its previously reported and predicted niche. We assembled location data on all recorded zoonotic transmission to humans and Ebola virus infection in bats and primates (1976-2014). Using species distribution models, these occurrence data were paired with environmental covariates to predict a zoonotic transmission niche covering 22 countries across Central and West Africa. Vegetation, elevation, temperature, evapotranspiration, and suspected reservoir bat distributions define this relationship. At-risk areas are inhabited by 22 million people; however, the rarity of human outbreaks emphasises the very low probability of transmission to humans. Increasing population sizes and international connectivity by air since the first detection of EVD in 1976 suggest that the dynamics of human-to-human secondary transmission in contemporary outbreaks will be very different to those of the past.

KEYWORDS:

Ebola; Ebola virus; boosted regression trees; disease mapping; epidemiology; global health; human; infectious disease; microbiology; niche based modelling; species distribution modelling; viruses

PMID:
25201877
PMCID:
PMC4166725
DOI:
10.7554/eLife.04395
[Indexed for MEDLINE]
Free PMC Article

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