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J Neurol Sci. 2014 Nov 15;346(1-2):204-8. doi: 10.1016/j.jns.2014.08.025. Epub 2014 Aug 27.

Parasomnias and isolated sleep symptoms in Parkinson's disease: a questionnaire study on 661 patients.

Author information

1
Vitalmed Research Center, Helsinki Sleep Clinic, Helsinki, Finland; Hospital of Laakso, Department of Neurology, Helsinki, Finland. Electronic address: ari.ylikoski@fimnet.fi.
2
The Finnish Parkinson Association, The Finnish Parkinson Foundation, Turku, Finland.
3
Vitalmed Research Center, Helsinki Sleep Clinic, Helsinki, Finland; Institute of Clinical Medicine, Department of Clinical Neurosciences, University of Helsinki, Helsinki, Finland.

Abstract

BACKGROUND:

Sleep disorders are among the most common non-motor symptoms in Parkinson's disease.

METHOD:

The prevalence of parasomnias and their association with other symptoms were studied in a questionnaire study among 1447 randomly selected Parkinson patients, aged 43 to 89 years. The response rate was 59.0% and of these 77% had answered to all questions that were used in the analyses (N = 661).

RESULTS:

The prevalence of REM sleep behavior disorder (RBD) evaluated by the RBDSQ ≥ 6 was 39.0%. The occurrences of other parasomnias (≥ 1/week) in patients with PD were: nightmares 17.2%, night terrors 3.9%, sleepwalking 1.8%, enuresis 21.0%, and hallucinations 15.3%. Occurrences (≥ 1/week) of the isolated sleep symptoms were: nocturnal sweating 28.8%, bruxism 4.7%, and sleep talking 21.7%. Association of RBD with sleepwalking (parasomnia overlap disorder) was found in 1.7% of all PD patients. Adjusted logistic regression analysis showed that weekly nightmares (OR 12.5; 95% CI 5.3 to 29.7), hallucinations (OR 5.1; 2.1 to 12.4), sleep talking (OR 11.6; 5.9 to 22.8), male gender (OR 1.9; 1.1 to 3.1), and restless legs syndrome (OR 4.7; 1.7 to 13.2) associated with the presence of RBD.

CONCLUSION:

Parkinson patients with RBD have often also other parasomnias and/or isolated sleep symptoms.

KEYWORDS:

Isolated sleep symptoms; Other parasomnias; Parkinson's disease; RBD; Sleep

PMID:
25201715
DOI:
10.1016/j.jns.2014.08.025
[Indexed for MEDLINE]

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