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Trends Mol Med. 2014 Oct;20(10):579-88. doi: 10.1016/j.molmed.2014.08.001. Epub 2014 Sep 5.

The current epidemiology and clinical decisions surrounding acute respiratory infections.

Author information

1
Center for Applied Genomics and Precision Medicine, Duke University School of Medicine, Durham, NC, USA; Department of Medicine, Duke University School of Medicine, Durham, NC, USA. Electronic address: aimee.zaas@duke.edu.
2
Center for Applied Genomics and Precision Medicine, Duke University School of Medicine, Durham, NC, USA.
3
Center for Applied Genomics and Precision Medicine, Duke University School of Medicine, Durham, NC, USA; Department of Medicine, Duke University School of Medicine, Durham, NC, USA; Durham Veterans Affairs Medical Center, Durham, NC, USA.

Abstract

Acute respiratory infection (ARI) is a common diagnosis in outpatient and emergent care settings. Currently available diagnostics are limited, creating uncertainty in the use of antibacterial, antiviral, or supportive care. Up to 72% of ambulatory care patients with ARI are treated with an antibacterial, despite only a small fraction actually needing one. Antibiotic overuse is not restricted to ambulatory care: ARI accounts for approximately 5 million emergency department (ED) visits annually in the USA, where 52-61% of such patients receive antibiotics. Thus, an accurate test for the presence or absence of viral or bacterial infection is needed. In this review, we focus on recent research showing that the host-response (genomic, proteomic, or miRNA) can accomplish this task.

KEYWORDS:

genomics; host–pathogen interaction; viral respiratory infection

PMID:
25201713
DOI:
10.1016/j.molmed.2014.08.001
[Indexed for MEDLINE]

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