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J Biochem Mol Toxicol. 2015 Jan;29(1):35-42. doi: 10.1002/jbt.21604. Epub 2014 Sep 9.

Protective effects of pterostilbene against acetaminophen-induced hepatotoxicity in rats.

Author information

1
Pharmacology and Toxicology Department, Faculty of Pharmacy, Al-Azhar University, Nasr-City, Cairo, Egypt. elsayed200_1956@hotmail.com.

Abstract

The present study was undertaken to evaluate the protective effect of pterostilbene against acetaminophen-induced hepatotoxicity. Silymarin was used as a standard hepatoprotective agent. A single dose of acetaminophen (800 mg/kg i.p.), injected to male rats, caused significant increases in serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, bilirubin, total cholesterol, triglycerides, tumor necrosis factor alpha, and hepatic contents of malondialdehyde, nitric oxide, caspase-3, hydroxyproline, with significant decreases in serum HDL-cholesterol, total proteins, albumin, and hepatic activities of reduced glutathione, superoxide dismutase and catalase as compared with the control group. On the other hand, administration of each of pterostilbene (50 mg/kg, p.o.) and silymarin (100 mg/kg, p.o.) for 15 days before acetaminophen ameliorated liver function and oxidative stress parameters. Histopathological evidence confirmed the protection offered by pterostilbene from the tissue damage caused by acetaminophen. In conclusion, pterostilbene possesses multimechanistic hepatoprotective activity that can be attributed to its antioxidant, anti-inflammatory, and antiapoptotic actions.

KEYWORDS:

Acetaminophen; Antioxidant; Hepatotoxicity; Pterostilbene; Silymarin

PMID:
25201704
DOI:
10.1002/jbt.21604
[Indexed for MEDLINE]

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