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Virus Res. 2015 Jan 2;195:43-6. doi: 10.1016/j.virusres.2014.08.019. Epub 2014 Sep 6.

Assessment of the antiviral properties of recombinant surfactant protein D against influenza B virus in vitro.

Author information

1
Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands.
2
Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
3
Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands; Viroclinics Biosciences BV, Rotterdam, The Netherlands.
4
Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands; Viroclinics Biosciences BV, Rotterdam, The Netherlands. Electronic address: g.rimmelzwaan@erasmusmc.nl.

Abstract

The armamentarium of antiviral drugs against influenza viruses is limited. Furthermore, influenza viruses emerge that are resistant to existing antiviral drugs like the M2 and NA inhibitors. Therefore, there is an urgent need for the development of novel classes of antiviral drugs. Here we investigated the antiviral properties of recombinant porcine surfactant protein D (RpSP-D), an innate defense molecule with lectin properties, against influenza B viruses. We have previously shown that porcine SP-D has more potent neutralizing activity against influenza A viruses than human SP-D. Here we show that RpSP-D neutralizes influenza B viruses efficiently and inhibited the binding of these viruses to epithelial cells of the human trachea.

KEYWORDS:

Antiviral; Influenza; Surfactant protein D

PMID:
25200748
DOI:
10.1016/j.virusres.2014.08.019
[Indexed for MEDLINE]

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