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Med Hypotheses. 2014 Nov;83(5):599-606. doi: 10.1016/j.mehy.2014.08.011. Epub 2014 Aug 23.

Pathophysiological dilemmas of lipedema.

Author information

1
Department of Dermatology and Allergology, University of Szeged, Faculty of Medicine, Koranyi fasor 6-8, 6720 Szeged, Hungary. Electronic address: szeledit@hotmail.com.
2
Department of Dermatology and Allergology, University of Szeged, Faculty of Medicine, Koranyi fasor 6-8, 6720 Szeged, Hungary.

Abstract

Lipedema is a common, but often underdiagnosed masquerading disease of obesity, which almost exclusively affects females. There are many debates regarding the diagnosis as well as the treatment strategies of the disease. The clinical diagnosis is relatively simple, however, knowledge regarding the pathomechanism is less than limited and curative therapy does not exist at all demanding an urgent need for extensive research. According to our hypothesis, lipedema is an estrogen-regulated polygenetic disease, which manifests in parallel with feminine hormonal changes and leads to vasculo- and lymphangiopathy. Inflammation of the peripheral nerves and sympathetic innervation abnormalities of the subcutaneous adipose tissue also involving estrogen may be responsible for neuropathy. Adipocyte hyperproliferation is likely to be a secondary phenomenon maintaining a vicious cycle. Herein, the relevant articles are reviewed from 1913 until now and discussed in context of the most likely mechanisms leading to the disease, which could serve as a starting point for further research.

PMID:
25200646
DOI:
10.1016/j.mehy.2014.08.011
[Indexed for MEDLINE]

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