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J Sci Food Agric. 2015 Mar 15;95(4):786-98. doi: 10.1002/jsfa.6903. Epub 2014 Oct 16.

Phytochemical screening, anticancer and antioxidant activities of Origanum vulgare L. ssp. viride (Boiss.) Hayek, a plant of traditional usage.

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1
Department of Chemistry, Faculty of Natural Sciences, Cankiri Karatekin University, 18100, Cankiri, Turkey.

Abstract

BACKGROUND:

A detailed phytochemical analysis of Origanum vulgare L. ssp. viride (Boiss.) Hayek was carried out and the antioxidant activities of five different crude extracts were determined. The antiproliferative activities of the extracts were determined using the xCELLigence system (Real Time Cell Analyzer).

RESULTS:

Differences between the essential oil and volatile organic compound profiles of the plant were shown. The main component of the essential oil was caryophyllene oxide, while the main volatile organic compounds were sabinene and eucalyptol as determined by HS-GC/MS. Phenolic contents of the extracts were determined qualitatively and quantitatively by HPLC/TOF-MS. Ten phenolic compounds were found in the extracts from O. vulgare and Origanum acutidens: rosmarinic acid (in highest abundance), chicoric acid, caffeic acid, p-coumaric acid, gallic acid, quercetin, apigenin-7-glucoside, kaempferol, naringenin and 4-hydroxybenzaldehyde.

CONCLUSION:

This study provides first results on the antiproliferative and antioxidant properties and detailed phytochemical screening of O. vulgare ssp. viride (Boiss.) Hayek.

KEYWORDS:

Origanum acutidens; Origanum vulgare ssp. viride; antioxidant; antiproliferative; phenolics

PMID:
25200133
DOI:
10.1002/jsfa.6903
[Indexed for MEDLINE]

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