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Metabolism. 2015 Jan;64(1):24-34. doi: 10.1016/j.metabol.2014.08.004. Epub 2014 Aug 15.

Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism.

Author information

1
Department of Internal Medicine, Soonchunhyang University College of Medicine, Seoul, Republic of Korea.
2
Division of Endocrinology, Diabetes and Metabolism, and the Institute for Diabetes, Obesity and Metabolism, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. Electronic address: ahima@mail.med.upenn.edu.

Abstract

Leptin is secreted by adipose tissue and regulates energy homeostasis, neuroendocrine function, metabolism, immune function and other systems through its effects on the central nervous system and peripheral tissues. Leptin administration has been shown to restore metabolic and neuroendocrine abnormalities in individuals with leptin-deficient states, including hypothalamic amenorrhea and lipoatrophy. In contrast, obese individuals are resistant to leptin. Recombinant leptin is beneficial in patients with congenital leptin deficiency or generalized lipodystrophy. However, further research on molecular mediators of leptin resistance is needed for the development of targeted leptin sensitizing therapies for obesity and related metabolic diseases.

KEYWORDS:

Energy homeostasis; Hypothalamus; Leptin; Metabolism; Obesity

PMID:
25199978
PMCID:
PMC4267898
DOI:
10.1016/j.metabol.2014.08.004
[Indexed for MEDLINE]
Free PMC Article

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