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Brain Res. 2015 Dec 2;1628(Pt A):219-32. doi: 10.1016/j.brainres.2014.09.004. Epub 2014 Sep 6.

Role of corticostriatal circuits in context-induced reinstatement of drug seeking.

Author information

1
Behavioral Neuroscience Branch, IRP, NIDA, Baltimore, MD, USA; Florey Institute of Neuroscience & Mental Health, University of Melbourne, Parkville, VIC, Australia. Electronic address: nathan.marchant@nih.gov.
2
Behavioral Neuroscience Branch, IRP, NIDA, Baltimore, MD, USA.
3
Behavioral Neuroscience Branch, IRP, NIDA, Baltimore, MD, USA. Electronic address: jennifer.bossert@nih.gov.

Abstract

Drug addiction is characterized by persistent relapse vulnerability during abstinence. In abstinent drug users, relapse is often precipitated by re-exposure to environmental contexts that were previously associated with drug use. This clinical scenario is modeled in preclinical studies using the context-induced reinstatement procedure, which is based on the ABA renewal procedure. In these studies, context-induced reinstatement of drug seeking is reliably observed in laboratory animals that were trained to self-administer drugs abused by humans. In this review, we summarize neurobiological findings from preclinical studies that have focused on the role of corticostriatal circuits in context-induced reinstatement of heroin, cocaine, and alcohol seeking. We also discuss neurobiological similarities and differences in the corticostriatal mechanisms of context-induced reinstatement across these drug classes. We conclude by briefly discussing future directions in the study of context-induced relapse to drug seeking in rat models. Our main conclusion from the studies reviewed is that there are both similarities (accumbens shell, ventral hippocampus, and basolateral amygdala) and differences (medial prefrontal cortex and its projections to accumbens) in the neural mechanisms of context-induced reinstatement of cocaine, heroin, and alcohol seeking.

KEYWORDS:

Abstinence; Alcohol; Cocaine; Context; Craving; Cue; Drug self-administration; Extinction; Heroin; Punishment; Reinstatement; Relapse; Review

PMID:
25199590
PMCID:
PMC4362860
DOI:
10.1016/j.brainres.2014.09.004
[Indexed for MEDLINE]
Free PMC Article

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