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Int J Tuberc Lung Dis. 2014 Aug;18(8):952-7. doi: 10.5588/ijtld.14.0060.

Cytokine gene polymorphisms are associated with susceptibility to tuberculosis in an Amerindian population.

Author information

1
<label>*</label>Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
2
<label><sup>†</sup></label>Unidade de Epidemiologia e Estatística, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.
3
<label><sup>‡</sup></label>School of Human Evolution & Social Change, Arizona State University, Tempe, Arizona, USA.

Abstract

SETTING:

Cytokines play an important role in anti-tuberculosis immune response, combined with antigen-presenting cells and lymphocytes. Immune response gene polymorphisms have been reported to be associated with tuberculosis (TB) susceptibility in some but not all studies.

OBJECTIVE:

To evaluate the association of immune response genes with susceptibility to tuberculin skin test (TST) reactivity and/or TB.

DESIGN:

Fourteen single nucleotide polymorphisms were genotyped in 96 individuals of the Aché, a native Paraguayan population, by allelic discrimination using real-time polymerase chain reaction. Univariate and multivariate Poisson regression were employed to assess risk genotypes.

RESULTS:

A higher prevalence of purified protein derivative reactivity was associated with the TNF-α CCA/TCG haplotype (PR 1.298, 95%CI 1.059-1.589) and with the IL-10 AT/CC diplotype (PR 1.181, 95% CI 1.024-1.362), and the presence of the IL-8 rs4073 T allele was associated with protection against TB (PR 0.482, 95%CI 0.273-0.851).

CONCLUSIONS:

These results suggest that polymorphisms in genes associated with immune response are involved in TST reactivity and susceptibility to TB in the Aché population.

PMID:
25199010
DOI:
10.5588/ijtld.14.0060
[Indexed for MEDLINE]

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