Format

Send to

Choose Destination
Int J Tuberc Lung Dis. 2014 Aug;18(8):919-24. doi: 10.5588/ijtld.14.0072.

Isoniazid preventive treatment in children in two districts of South India: does practice follow policy?

Author information

1
<label>*</label>World Health Organization Country Office in India, New Delhi.
2
<label><sup>†</sup></label>Revised National TB Control Programme (RNTCP) District Tuberculosis Unit, Krishnagiri and Dharmapuri Districts, Tamilnadu.
3
<label><sup>‡</sup></label>RNTCP State Tuberculosis Unit, Tamilnadu.
4
<label><sup>§</sup></label>International Union Against Tuberculosis and Lung Disease, South-East Asia Regional Office, New Delhi, India.
5
<label><sup>¶</sup></label>Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Abstract

SETTING:

Two districts of Tamil Nadu, India

OBJECTIVES:

To determine the proportion of household contacts aged <6 years of patients with tuberculosis (TB) with positive sputum microscopy results who initiated and completed isoniazid preventive treatment (IPT), and to determine reasons for non-initiation and non-completion of IPT.

DESIGN:

Household visits were conducted on a random sample of adult patients registered during January-June 2012 to identify household contacts aged <6 years.

RESULTS:

Among 271 children living with 691 index patients, 218 (80%) were evaluated and 9 (4%) were diagnosed with TB. Of 209 remaining contacts, 70 (33%) started IPT and 16 (22.9%) completed a full course of IPT. Of 139 contacts who did not start IPT, five developed TB disease. Reasons for non-initiation of IPT included no home visit by the field staff (19%) and no education about IPT (61%). Reasons for non-completion included isoniazid not provided (52%) and long duration of treatment (28%).

CONCLUSION:

This study shows that Revised National TB Programme guidance was not being followed and IPT implementation was poor. Poor IPT uptake represents a missed opportunity to prevent future TB cases. Provision of IPT may be improved through training, improved logistics and enhanced supervision and monitoring.

PMID:
25199005
PMCID:
PMC4589200
DOI:
10.5588/ijtld.14.0072
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Ingenta plc Icon for PubMed Central
Loading ...
Support Center