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J Enzyme Inhib Med Chem. 2015 Jun;30(3):505-13. doi: 10.3109/14756366.2014.944178. Epub 2014 Sep 8.

Drosophila melanogaster: a model organism for controlling Dipteran vectors and pests.

Author information

1
School of Medicine, University of Tampere , Tampere , Finland .

Abstract

Beta-carbonic anhydrases (β-CAs) have been recently reported to be present in many protozoan and metazoan species, whereas it is absent in mammals. In this review, we introduce β-CA from Drosophila melanogaster as a model enzyme for pesticide development. These enzymes can be targeted with various enzyme inhibitors, which can have deleterious effects on pathogenic and other harmful organisms. Therefore, β-CAs represent a new potential target to fight against Dipteran vectors and pests relevant to medicine, veterinary medicine, and agriculture.

KEYWORDS:

Carbonic anhydrase; Dipteran; Drosophila melanogaster; inhibitors; pesticides

PMID:
25198895
DOI:
10.3109/14756366.2014.944178
[Indexed for MEDLINE]

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