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Int J Environ Res Public Health. 2014 Sep 5;11(9):9156-70. doi: 10.3390/ijerph110909156.

A dose-response relationship between organic mercury exposure from thimerosal-containing vaccines and neurodevelopmental disorders.

Author information

1
Institute of Chronic Illnesses, Inc., 14 Redgate Ct., Silver Spring, MD 20905, USA. davidallengeier@comcast.net.
2
Department of Biology, Simpson University, 2211 College View Dr., Redding, CA 96003, USA. bhooker@simpsonu.edu.
3
Institute of Chronic Illnesses, Inc., 14 Redgate Ct., Silver Spring, MD 20905, USA. jkern@dfwair.net.
4
CoMeD, Inc., 14 Redgate Ct., Silver Spring, MD 20905, USA. paulgkingphd@gmail.com.
5
CoMeD, Inc., 14 Redgate Ct., Silver Spring, MD 20905, USA. syklone5@verizon.net.
6
Institute of Chronic Illnesses, Inc., 14 Redgate Ct., Silver Spring, MD 20905, USA. mgeier@comcast.net.

Abstract

A hypothesis testing case-control study evaluated concerns about the toxic effects of organic-mercury (Hg) exposure from thimerosal-containing (49.55% Hg by weight) vaccines on the risk of neurodevelopmental disorders (NDs). Automated medical records were examined to identify cases and controls enrolled from their date-of-birth (1991-2000) in the Vaccine Safety Datalink (VSD) project. ND cases were diagnosed with pervasive developmental disorder (PDD), specific developmental delay, tic disorder or hyperkinetic syndrome of childhood. In addition, putative non-thimerosal-related outcomes of febrile seizure, failure to thrive and cerebral degenerations were examined. The cumulative total dose of Hg exposure from thimerosal-containing hepatitis B vaccine (T-HBV) administered within the first six months of life was calculated. On a per microgram of organic-Hg basis, PDD (odds ratio (OR) = 1.054), specific developmental delay (OR = 1.035), tic disorder (OR = 1.034) and hyperkinetic syndrome of childhood (OR = 1.05) cases were significantly more likely than controls to receive increased organic-Hg exposure. By contrast, none of the non-thimerosal related outcomes were significantly more likely than the controls to have received increased organic-Hg exposure. Routine childhood vaccination may be an important public health tool to reduce infectious disease-associated morbidity/mortality, but the present study significantly associates organic-Hg exposure from T-HBV with an increased risk of an ND diagnosis.

PMID:
25198681
PMCID:
PMC4199012
DOI:
10.3390/ijerph110909156
[Indexed for MEDLINE]
Free PMC Article

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