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PLoS One. 2014 Sep 8;9(9):e101480. doi: 10.1371/journal.pone.0101480. eCollection 2014.

Intrinsic differences between oral and skin keratinocytes.

Author information

1
Center for Wound Healing and Tissue Regeneration, College of Dentistry, University of Illinois at Chicago, Chicago, Illinois, United States of America.
2
The Richard and Loan Hill Department of Bioengineering, College of Engineering, University of Illinois at Chicago, Chicago, Illinois, United States of America.
3
Oregon Health and Science University, School of Dentistry, Portland, Oregon, United States of America.

Abstract

Keratinocytes cover both the skin and some oral mucosa, but the morphology of each tissue and the behavior of the keratinocytes from these two sites are different. One significant dissimilarity between the two sites is the response to injury. Oral mucosal wounds heal faster and with less inflammation than equivalent cutaneous wounds. We hypothesized that oral and skin keratinocytes might have intrinsic differences at baseline as well as in the response to injury, and that such differences would be reflected in gene expression profiles.

PMID:
25198578
PMCID:
PMC4157746
DOI:
10.1371/journal.pone.0101480
[Indexed for MEDLINE]
Free PMC Article

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