Circos plots are shown (left to right, in listed order) for the five most sensitive (H82, H446, H526, COR-L88, IST-SL1) and most resistant (DMS-114, H64, DMS-79, H2171, IST-SL2) SCLC cells to BI-2536 growth inhibition, as defined in the CGP study. The outer black ring designates the chromosome location; the next inner ring indicates expression level of PLK signature genes; and the inner most ring indicates CNV. CNV data was re-coded according to the following rule: 0 complete loss; 1 partial loss; 2 no change; 3∼7 partial gain; greater or equal to 8 complete gain. At the center is the mutation status of genes (open triangle: intronic SNP, black circle: missense SNP, black square: nonsense SNP, red triangle: frame-shift insertion, green triangle: frame-shift deletion). All mutations were homozygous except for the frame-shift insertion.