Format

Send to

Choose Destination
See comment in PubMed Commons below
Annu Rev Genet. 2014;48:269-94. doi: 10.1146/annurev-genet-111212-133531. Epub 2014 Sep 5.

From egg to gastrula: how the cell cycle is remodeled during the Drosophila mid-blastula transition.

Author information

1
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138; email: jfarrell@g.harvard.edu.

Abstract

Many, if not most, embryos begin development with extremely short cell cycles that exhibit unusually rapid DNA replication and no gap phases. The commitment to the cell cycle in the early embryo appears to preclude many other cellular processes that only emerge as the cell cycle slows just prior to gastrulation at a major embryonic transition known as the mid-blastula transition (MBT). As reviewed here, genetic and molecular studies in Drosophila have identified changes that extend S phase and introduce a post-replicative gap phase, G2, to slow the cell cycle. Although many mysteries remain about the upstream regulators of these changes, we review the core mechanisms of the change in cell cycle regulation and discuss advances in our understanding of how these might be timed and triggered. Finally, we consider how the elements of this program may be conserved or changed in other organisms.

KEYWORDS:

Drosophila; G2; MBT; cell cycle; maternal-zygotic transition; replication

[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon Icon for PubMed Central
    Loading ...
    Support Center