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Food Chem Toxicol. 2014 Dec;74:9-13. doi: 10.1016/j.fct.2014.08.014. Epub 2014 Sep 3.

Dietary supplementation with tomato-juice in patients with metabolic syndrome: a suggestion to alleviate detrimental clinical factors.

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General Chemical State Laboratory of Greece, 16 An. Tsocha Str., 11521, Athens, Greece.
Cardiology Department, General Hospital of Karditsa, Terma Tavropou, Karditsa, Greece.
Doping Control Laboratory of Athens, Olympic Athletic Centre of Athens, Kiffisias 37, 151 23, Maroussi, Greece.
Clinic II for Nephrology and Endocrinology, Department for Internal Medicine, Alfrief Krupp Hospital, Alfried Krupp Str.49, 45131 Essen, Germany.
Laboratory of Toxicology, Medical School, University of Crete, Voutes, 71409 Heraklion, Crete, Greece.
ORTHOBIOTIKI Prevention and Anti-aging, Private Practice, 3-5 Sorou St., 15125, Athens, Greece.
Second Cardiology Department, Amalia Fleming General Hospital, 14 25th Martiou Str., 15127, Athens, Greece.
Harvard School of Public Health, Boston, MA, USA.
Laboratory of Toxicology, Medical School, University of Crete, Voutes, 71409 Heraklion, Crete, Greece. Electronic address:


Lycopene, a carotenoid, is known for its antioxidant properties. Little is known, though, about the relationship of dietary tomato-juice intake and risks factors, like inflammation, insulin resistance and hyperlipidemia, implicated in metabolic syndrome. In the present study, we examined whether supplementation with tomato-juice has any implication on the risk status of patients with metabolic syndrome. A comparative study was conducted in 27 individuals diagnosed with metabolic syndrome. Fifteen of them were instructed to use commercially available tomato-juice as refreshment 4 times a week over a period of two months and twelve individuals served as the control group. Several parameters reflective of the metabolic syndrome were monitored both in the group supplemented with tomato juice and in the control group (ADMA for entdothelial function, TNF-α and IL-6 for inflammation, FIRI for insulin resistance). There was a significant improvement in the inflammation status and the endothelial dysfunction of the tomato-juice supplemented patients. At the same time, insulin resistance improved and a pronounced decrease in LDL was recorded, along with a slight increase in HDL. The results of the present study suggest an alleviating effect of tomato-juice with regard to risk factors associated with metabolic syndrome.


Inflammation; Insulin resistance; Metabolic syndrome; Tomato juice

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