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Contraception. 2015 Jan;91(1):67-70. doi: 10.1016/j.contraception.2014.08.004. Epub 2014 Aug 12.

Postpartum glucose tolerance in women with gestational diabetes using levonorgestrel intrauterine contraception.

Author information

1
Department of Obstetrics & Gynecology, Northwestern University, Feinberg School of Medicine, 676 N. St. Clair Street, Suite 1315, Chicago, IL 60611. Electronic address: jkiley@nmff.org.
2
Department of Obstetrics & Gynecology, Northwestern University, Feinberg School of Medicine, 676 N. St. Clair Street, Suite 1315, Chicago, IL 60611.
3
Department of Preventative Medicine, Northwestern University, Feinberg School of Medicine, 680 N. Lake Shore Drive, Suite 1400, Chicago, IL 60611.

Abstract

OBJECTIVE:

Postpartum contraception is critical in women with gestational diabetes mellitus (GDM). We evaluated the effect of the levonorgestrel intrauterine system (LNG-IUS) on glucose tolerance in postpartum women with GDM.

STUDY DESIGN:

The study is a descriptive analysis of 12-month glucose tolerance in women with recent GDM who used the LNG-IUS, the copper IUD or postpartum sterilization.

RESULTS:

Twelve months postpartum, 3 of 13 LNG-IUS users (23.1%) and 1 of 6 nonhormonal contraceptive users (16.6%) had prediabetes. No woman developed overt diabetes.

CONCLUSIONS:

This study is the first and only to measure the metabolic effects of the LNG-IUS women with GDM. Larger trials are necessary.

IMPLICATIONS:

Use of levonorgestrel intrauterine contraception does not appear to negatively affect glucose tolerance in postpartum women with a history of gestational diabetes. Additional appropriately powered clinical studies are needed to confirm these results.

KEYWORDS:

Gestational diabetes; Glucose tolerance; Intrauterine device; LARC; Postpartum contraception

[Indexed for MEDLINE]

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