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Am J Respir Cell Mol Biol. 2015 Feb;52(2):139-51. doi: 10.1165/rcmb.2014-0166TR.

MicroRNAs in pulmonary arterial hypertension.

Author information

1
1 Department of Pediatrics, University of Illinois at Chicago; and.

Abstract

Pulmonary arterial hypertension (PAH) is a devastating disease without effective treatment. Despite decades of research and the development of novel treatments, PAH remains a fatal disease, suggesting an urgent need for better understanding of the pathogenesis of PAH. Recent studies suggest that microRNAs (miRNAs) are dysregulated in patients with PAH and in experimental pulmonary hypertension. Furthermore, normalization of a few miRNAs is reported to inhibit experimental pulmonary hypertension. We have reviewed the current knowledge about miRNA biogenesis, miRNA expression pattern, and their roles in regulation of pulmonary artery smooth muscle cells, endothelial cells, and fibroblasts. We have also identified emerging trends in our understanding of the role of miRNAs in the pathogenesis of PAH and propose future studies that might lead to novel therapeutic strategies for the treatment of PAH.

KEYWORDS:

fibroblasts; microRNA; pulmonary arterial hypertension; pulmonary artery endothelial cells; pulmonary artery smooth muscle cell

PMID:
25192340
PMCID:
PMC4370247
DOI:
10.1165/rcmb.2014-0166TR
[Indexed for MEDLINE]
Free PMC Article

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