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Front Immunol. 2014 Aug 21;5:389. doi: 10.3389/fimmu.2014.00389. eCollection 2014.

Regulatory T-cells in pregnancy: historical perspective, state of the art, and burning questions.

Author information

1
Sorbonne Université, UPMC Univ Paris 06, UMRS 959, Immunology-Immunopathology-Immunotherapy (I3) , Paris , France ; INSERM, UMRS 959, Immunology-Immunopathology-Immunotherapy (I3) , Paris , France.
2
INSERM, U 976, Hôpital Saint Louis , Paris , France.
3
Sorbonne Université, UPMC Univ Paris 06, UMRS 959, Immunology-Immunopathology-Immunotherapy (I3) , Paris , France ; INSERM, UMRS 959, Immunology-Immunopathology-Immunotherapy (I3) , Paris , France ; AP-HP, Hôpital Pitié-Salpêtrière, Biotherapy (CIC-BTi) and Inflammation-Immunopathology-Biotherapy Department (i2B) , Paris , France.

Abstract

In this review, we first revisit the original concept of "suppressor T-cells" in pregnancy, put it in a historical perspective, and then highlight the main data that licensed its resurrection and revision into the concept of "regulatory T-cells" (Tregs) in pregnancy. We review the evidence for a major role of Tregs in murine and human pregnancy and discuss Treg interactions with dendritic and uterine natural killer cells, other players of maternal-fetal tolerance. Finally, we highlight what we consider as the most important questions in the field.

KEYWORDS:

NK cells; Treg; cancer tolerance; evolution of the immune system; suppressor T-cells

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