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Saudi J Anaesth. 2014 Jul;8(3):374-7. doi: 10.4103/1658-354X.136436.

Comparing the effect of pregabalin, gabapentin, and acetaminophen on post-dural puncture headache.

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Department of Anesthesiology and Pain Medicine, Imam Khomeini Training Hospital, Urmia University of Medical Sciences, Urmia, Iran.



Post-dural puncture headache (PDPH) is a common complication of lumbar puncture for any purpose. To avoid the need for invasive methods of treating PDPH such as blood patch, the search for novel pharmacological agents to manage PDPH continues. The aim of this study was to compare the effects of acetaminophen, gabapentin and pregabalin in controlling PDPH in patients who underwent surgery under spinal anesthesia.


A total of 90 patients who underwent elective orthopedic surgery under spinal anesthesia and suffered from PDPH consequently were enrolled in this randomized trial. Patients were categorized randomly into three groups. Group A, B and C have received Acetaminophen, Gabapentin and Pregabalin (3 times a day for 3 days), respectively. The effect of medications on the severity of PDPH was evaluated and compared using visual analog scale (VAS).


The mean VAS score was significantly lower in pregabalin group compared with others 24, 48 and 72 h after the onset of headache (P = 0.001 for all of them) and lower in Gabapentin group compared with Acetaminophen group 24, 48 and 72 h after the onset of headache (P = 0.001 for all analyses). No adverse outcome was reported in groups.


Pregabalin and gabapentin are both useful and safe in management of PDPH, but pregabalin is more effective in this regard.


Acetaminophen; gabapentin; post-dural puncture headache; pregabalin

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