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Org Lett. 2014 Sep 19;16(18):4774-7. doi: 10.1021/ol502227x. Epub 2014 Sep 4.

Oxazinin A, a pseudodimeric natural product of mixed biosynthetic origin from a filamentous fungus.

Author information

1
Department of Medicinal Chemistry and ‡Department of Pharmacology and Toxicology, L. S. Skaggs Pharmacy Institute, University of Utah , Salt Lake City, Utah 84112 United States.

Abstract

A racemic, prenylated polyketide dimer, oxazinin A (1), was isolated from a novel filamentous fungus in the class Eurotiomycetes, and its structure was elucidated spectroscopically. The pentacyclic structure of oxazinin A (1) is a unique combination of benzoxazine, isoquinoline, and a pyran ring. Oxazinin A (1) exhibited antimycobacterial activity and modestly antagonized transient receptor potential (TRP) channels.

PMID:
25188821
PMCID:
PMC4168773
DOI:
10.1021/ol502227x
[Indexed for MEDLINE]
Free PMC Article

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