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Cancer Immunol Res. 2014 Sep;2(9):831-8. doi: 10.1158/2326-6066.CIR-14-0069.

Combining radiation and immunotherapy: a new systemic therapy for solid tumors?

Author information

1
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
2
University of California Irvine School of Medicine, Irvine, California.
3
Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
4
Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
5
Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
6
Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
7
Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
8
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. JWelsh@mdanderson.org.

Abstract

With the recent success of checkpoint inhibitors and other immunomodulating agents, there has been renewed interest in the combination of such agents with radiation. The biologic premise behind such a strategy is that the tumor-antigen release achieved by localized radiation will promote specific tumor targeting by the adaptive immune system, which can be augmented further by systemic immune-stimulating agents. In this manner, clinicians hope to induce a phenomenon known as the abscopal effect, whereby localized radiation results in immune-mediated tumor regression in disease sites well outside of the radiation field. Herein, we present a comprehensive overview of the early clinical and preclinical evidence behind this approach.

PMID:
25187273
PMCID:
PMC5367158
DOI:
10.1158/2326-6066.CIR-14-0069
[Indexed for MEDLINE]
Free PMC Article

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