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Immunotherapy. 2014;6(6):755-74. doi: 10.2217/imt.14.37.

Peptides and peptidomimetics as immunomodulators.

Author information

1
Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71201, USA.

Abstract

Peptides and peptidomimetics can function as immunomodulating agents by either blocking the immune response or stimulating the immune response to generate tolerance. Knowledge of B- or T-cell epitopes along with conformational constraints is important in the design of peptide-based immunomodulating agents. Work on the conformational aspects of peptides, synthesis and modified amino acid side chains have contributed to the development of a new generation of therapeutic agents for autoimmune diseases and cancer. The design of peptides/peptidomimetics for immunomodulation in autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, systemic lupus and HIV infection is reviewed. In cancer therapy, peptide epitopes are used in such a way that the body is trained to recognize and fight the cancer cells locally as well as systemically.

KEYWORDS:

T-cell epitope; cyclotide; immunomodulation; peptide-based vaccine; peptidomimetics; β-amino acid

PMID:
25186605
PMCID:
PMC4201125
DOI:
10.2217/imt.14.37
[Indexed for MEDLINE]
Free PMC Article

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