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Eur Respir J. 2015 Feb;45(2):328-37. doi: 10.1183/09031936.00060214. Epub 2014 Sep 3.

Early exposure to bio-contaminants and asthma up to 10 years of age: results of the HITEA study.

Author information

1
Institute of Epidemiology I, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany christina.tischer@helmholtz-muenchen.de.
2
Dept of Public Health and Primary Care - Centre for Environment and Health KU Leuven, Leuven, Belgium Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
3
Institute for Risk Assessment Sciences, Division Environmental Epidemiology, Utrecht University, Utrecht, The Netherlands.
4
Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
5
Dept Environmental Health, National Institute for Health and Welfare, Kuopio, Finland.
6
University Medical Center Groningen, Dept of Epidemiology, University of Groningen, Groningen, The Netherlands.
7
Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain University Pompeu Fabra, Barcelona, Spain.
8
Institute of Epidemiology I, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany.
9
Institute of Epidemiology I, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany Division of Metabolic Diseases and Nutritional Medicine, Dr von Hauner Children's Hospital, Ludwig-Maximilians-University, Munich, Germany.
10
Area de Salud de Menorca, IB-SALUT, Mahon, Spain.

Abstract

Inverse associations have been found between exposure to bio-contaminants and asthma and allergies. The aim of this study was to prospectively assess whether early exposure to bio-contaminants in dust is associated with asthma and allergy later in childhood among children from (sub)-urban areas. In subsets of three European birth cohorts (PIAMA: n=553; INMA: n=481; and LISAplus: n=395), endotoxin, (1,3,)-β-d-glucan and extracellular polysaccharide were measured in dust from living rooms shortly after birth. Current asthma at 6 years and 10 years of age and ever asthma up to 10 years of age were assessed by parental questionnaires. Specific IgE levels at 8 years (PIAMA) and 10 years (LISAplus) were available. Adjusted, cohort-specific logistic regression analyses were performed. Higher endotoxin concentrations were positively associated with current asthma at 6 years of age in PIAMA (adjusted OR 1.96, 95% CI 1.07-3.58), but were inversely related with ever asthma up to 10 years of age in INMA (adjusted OR 0.39, 95% CI 0.16-0.94). No associations with asthma were found for LISAplus. No associations were observed with atopic sensitisation in all cohorts. All associations with (1,3)-β-d-glucan and extracellular polysaccharide were statistically nonsignificant. The suggested immunological mechanisms of early exposure to bio-contaminants with regards to asthma and allergy might be different for children growing up in (sub)-urban environments.

PMID:
25186271
DOI:
10.1183/09031936.00060214
[Indexed for MEDLINE]
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