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Nat Rev Neurosci. 2014 Oct;15(10):683-95. doi: 10.1038/nrn3801. Epub 2014 Sep 4.

Modern network science of neurological disorders.

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Department of Neurology and Clinical Neurophysiology, MEG Center, VU University Medical Center, De Boelelaan 1118, 1081HV Amsterdam, The Netherlands.


Modern network science has revealed fundamental aspects of normal brain-network organization, such as small-world and scale-free patterns, hierarchical modularity, hubs and rich clubs. The next challenge is to use this knowledge to gain a better understanding of brain disease. Recent developments in the application of network science to conditions such as Alzheimer's disease, multiple sclerosis, traumatic brain injury and epilepsy have challenged the classical concept of neurological disorders being either 'local' or 'global', and have pointed to the overload and failure of hubs as a possible final common pathway in neurological disorders.

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