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Cold Spring Harb Perspect Med. 2014 Sep 2;4(9):a013888. doi: 10.1101/cshperspect.a013888.

Cardiac cell lineages that form the heart.

Author information

1
Institut Pasteur, Department of Developmental and Stem Cell Biology, CNRS URA2578, 75015 Paris, France.
2
Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium.
3
Université Libre de Bruxelles, IRIBHM, Brussels B-1070, Belgium WELBIO, Université Libre de Bruxelles, Brussels B-1070, Belgium.

Erratum in

Abstract

Myocardial cells ensure the contractility of the heart, which also depends on other mesodermal cell types for its function. Embryological experiments had identified the sources of cardiac precursor cells. With the advent of genetic engineering, novel tools have been used to reconstruct the lineage tree of cardiac cells that contribute to different parts of the heart, map the development of cardiac regions, and characterize their genetic signature. Such knowledge is of fundamental importance for our understanding of cardiogenesis and also for the diagnosis and treatment of heart malformations.

PMID:
25183852
PMCID:
PMC4143102
DOI:
10.1101/cshperspect.a013888
[Indexed for MEDLINE]
Free PMC Article

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