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Neuron. 1989 Sep;3(3):359-65.

Dynamic alterations occur in the levels and composition of transcription factor AP-1 complexes after seizure.

Author information

1
Department of Molecular Oncology and Virology, Roche Research Center, Nutley, New Jersey 07110.

Abstract

Seizure causes a rapid and protracted increase in transcription factor AP-1 levels in the brain. The composition of AP-1 nucleoprotein complexes changes with time after seizure as a result of the sequential appearance and disappearance of Fos and several Fos-related proteins. Although these changes occur over an 8 hr time period, they are triggered by 15 min of seizure. Alterations in the levels and composition of transcription factors may represent one of the molecular mechanisms underlying neuronal adaptation.

PMID:
2518370
DOI:
10.1016/0896-6273(89)90260-2
[Indexed for MEDLINE]

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