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Acta Physiol Hung. 2014 Sep;101(3):309-20. doi: 10.1556/APhysiol.101.2014.3.6.

Genetic effects on refraction and correlation with hemodynamic variables: a twin study.

Author information

1
Semmelweis University Department of Ophthalmology Budapest Hungary.
2
Semmelweis University Department of Radiology and Oncotherapy Üllői út 78/a H-1082 Budapest Hungary.
3
Semmelweis University Department of Ophthalmology Budapest Hungary Szent György Hospital Department of Ophthalmology Székesfehérvár Hungary.
4
Central European University Budapest Hungary.
5
Semmelweis University School of Pharmacy Budapest Hungary.
6
Research Group for Inflammation Biology and Immunogenomics of Hungarian Academy of Sciences and Semmelweis University Budapest Hungary Military Hospital Department of Cardiology Budapest Hungary.
7
The Methodist Hospital DeBakey Heart and Vascular Center Houston TX USA.

Abstract

Spherical equivalent (SE) has not been linked to increased cardiovascular morbidity.

METHODS:

132 Hungarian twins(age 43.3±16.9 years) underwent refraction measurements (Huvitz MRK-3100 Premium AutoRefractokeratometer)and oscillometry (TensioMed Arteriograph).

RESULTS:

Heritability analysis indicated major role for genetic components in the presence of right and left SE (82.7%, 95%CI, 62.9 to 93.7%, and 89.3%, 95%CI, 72.8 to 96.6%),while unshared environmental effects accounted for 17% (95%CI, 6.3% to 37%), and 11% (95%CI, 3.4% to 26.7%)of variations adjusted for age and sex. Bilateral SE showed weak age-dependent correlations with augmentation index (AIx), aortic pulse wave velocity (r ranging between 0.218 and 0.389, all p < 0.01), aortic systolic blood pressure and pulse pressure (r between 0.188 and 0.289, p < 0.05).

CONCLUSIONS:

These findings support heritability of spherical equivalent, which does not coexist with altered hemodynamics (e.g. accelerated arterial aging).Accordingly, SE and the investigated hemodynamic parameters seem neither phenotypically nor genetically associated.

KEYWORDS:

arterial stiffness; augmentation index; genetics; heritability; refraction

PMID:
25183505
DOI:
10.1556/APhysiol.101.2014.3.6
[Indexed for MEDLINE]

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