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Antimicrob Agents Chemother. 2014 Nov;58(11):6970-3. doi: 10.1128/AAC.03672-14. Epub 2014 Sep 2.

Antibacterial synergy of glycerol monolaurate and aminoglycosides in Staphylococcus aureus biofilms.

Author information

1
Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
2
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, USA.
3
Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, USA wells002@umn.edu.

Abstract

Glycerol monolaurate (GML) is a natural surfactant with antimicrobial properties. At ∼0.3 mM, both GML and its component lauric acid were bactericidal for antibiotic-resistant Staphylococcus aureus biofilms. With the use of MICs of antibiotics obtained from planktonic cells, GML and lauric acid acted synergistically with gentamicin and streptomycin, but not ampicillin or vancomycin, to eliminate detectable viable biofilm bacteria. Images of GML-treated biofilms suggested that GML may facilitate antibiotic interaction with matrix-embedded bacteria.

PMID:
25182634
PMCID:
PMC4249351
DOI:
10.1128/AAC.03672-14
[Indexed for MEDLINE]
Free PMC Article

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