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Trends Immunol. 2014 Oct;35(10):483-94. doi: 10.1016/j.it.2014.08.001. Epub 2014 Aug 30.

Tissue damage control in disease tolerance.

Author information

1
Rua da Quinta Grande, 6, 2780-156 Oeiras, Portugal. Electronic address: mpsoares@igc.gulbenkian.pt.
2
Rua da Quinta Grande, 6, 2780-156 Oeiras, Portugal.

Abstract

Immune-driven resistance mechanisms are the prevailing host defense strategy against infection. By contrast, disease tolerance mechanisms limit disease severity by preventing tissue damage or ameliorating tissue function without interfering with pathogen load. We propose here that tissue damage control underlies many of the protective effects of disease tolerance. We explore the mechanisms of cellular adaptation that underlie tissue damage control in response to infection as well as sterile inflammation, integrating both stress and damage responses. Finally, we discuss the potential impact of targeting these mechanisms in the treatment of disease.

KEYWORDS:

damage response; disease tolerance; infection; stress response; tissue damage control

PMID:
25182198
DOI:
10.1016/j.it.2014.08.001
[Indexed for MEDLINE]

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