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Br J Cancer. 2014 Oct 28;111(9):1824-30. doi: 10.1038/bjc.2014.479. Epub 2014 Sep 2.

Reduction of low- and high-grade cervical abnormalities associated with high uptake of the HPV bivalent vaccine in Scotland.

Author information

1
Health Protection Scotland, 5 Cadogan Street, Glasgow G2 6QE, Scotland.
2
Department of Mathematics and Statistics, University of Strathclyde, Level 8, Livingstone Tower, 26 Richmond St, Glasgow G1 1XH, Scotland.
3
Scottish Human Papillomavirus Reference Laboratory, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, Scotland.
4
University of Aberdeen, Health Sciences Building, Foresterhill, Aberdeen AB25 2ZD, Scotland.
5
Raigmore Department of Pathology, Raigmore Hospital, Old Perth Road, Inverness IV2 3UJ, Scotland.
6
Department of Cytology, Ninewells Hospital, Dundee DD1 9SY, Scotland.

Abstract

BACKGROUND:

In Scotland, a national HPV immunisation programme began in 2008 for 12- to 13-year olds, with a catch-up campaign from 2008 to 2011 for those under the age of 18. To monitor the impact of HPV immunisation on cervical disease at the population level, a programme of national surveillance was established.

METHODS:

We analysed colposcopy data from a cohort of women born between 1988 and 1992 who entered the Scottish Cervical Screening Programme (SCSP) and were aged 20-21 in 2008-2012.

RESULTS:

By linking datasets from the SCSP and colposcopy services, we observed a significant reduction in diagnoses of cervical intraepithelial neoplasia 1 (CIN 1; RR 0.71, 95% CI 0.58 to 0.87; P=0.0008), CIN 2 (RR 0.5, 95% CI 0.4 to 0.63; P<0.0001) and CIN 3 (RR 0.45, 95% CI 0.35 to 0.58; P<0.0001) for women who received three doses of vaccine compared with unvaccinated women.

CONCLUSIONS:

To our knowledge, this is one of the first studies to show a reduction of low- and high-grade CIN associated with high uptake of the HPV bivalent vaccine at the population level. These data are very encouraging for countries that have achieved high HPV vaccine uptake.

PMID:
25180766
PMCID:
PMC4453734
DOI:
10.1038/bjc.2014.479
[Indexed for MEDLINE]
Free PMC Article

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